Faculty - Cellular Biologist/Immunologist
Dr. Cathleen Ciesielski
Physician Assistant Studies
EducationDoctor of Philosophy, Cell Biology/Immunology
Clinical Practice ExperienceOrganic Chemist
Beech JT, Andreakos E, Ciesielski CJ, Green P, Foxwell BM, and Brennan FM. 2006 T cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NK-kappaB: implications for rheumatoid arthritis. Arthritis Res Ther. 8(6): R168.
Holderbaum D, Malvitz T, Ciesielski CJ, Carson D, Corr MP, and Moskowitz RW. 2005. A newly described hereditary cartilage debonding syndrome. Arthritis Rheum 52: 3300-4.
Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, Ferreira A, Ciesielski CJ, Carson D, and Corr M. 2004. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci USA 101:9757-62.
Campbell J, Ciesielski CJ, Hunt AE, Horwood NJ, Beech JT, Hayes LA, Denys A, Feldmann M, Brennan FM, and Foxwell BMJ. 2004. A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappaB with implications for therapy in rheumatoid arthritis. J Immunol 173: 6928-37.
Lindsay JO, Ciesielski CJ, Scheinin T, Brennan FM and Hodgson HJ. 2003. Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production is therapeutic for murine colitis. Gut 52:981-7.
Ciesielski CJ, Foxwell BMJ, and Feldmann M. 2002. TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than LPS-induced macrophage chemokine secretion. Euro J Immunol 32:2037-45
Brennan FM, Hayes AL, Ciesielski CJ, Green P, Foxwell BMJ and Feldmann M. 2002. Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis. Arthritis Rheum 46:31-41.
Denys A, Udalova IA, Smith C, Williams LM, Ciesielski CJ, Campbell J, Andrews C, Kwaitkowski D, Foxwell BM. 2002. Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages. J Immunol 15:4837-45.
Ciesielski CJ, Andreakos E, Brennan FM, Foxwell BMJ, and Feldmann M. 2002. Monocytic MIP-1alpha/beta, RANTES, MCP-1 production induced by cognate interaction with T cells is differentially dependent on NF-kappaB. Arthritis Rheum 48:85-92.
Lindsay JO, Ciesielski CJ, Scheinin T, Hodgson HJ and Brennan FM. 2001. The prevention and treatment of murine colitis using gene therapy with adenoviral vectors encoding interleukin-10. J Immunol 166: 7625-7633.
Ciesielski CJ, Mei J and Piccinini LA. 1998. Effects of cyclosporine A and methotrexate on CD18 expression in recipients of rat cardiac allografts. Transplant Immunology 6:122-133.
Ciesielski CJ, Pflug JJ, Mei J and Piccinini LA. 1998. Methotrexate regulates ICAM-1 expression in recipients of rat cardiac allografts. Transplant Immunology 6:111-121.
Ciesielski CJ, Mei J, Neton JT and Piccinini LA. 1997. Effects of cyclosporine A and methotrexate upon induction of TNFa in rat cardiac allografts. Transplant Immunology 5:25-37.
Research and Presentations
Padgett J, Ciesielski CJ. ” The Metabolism of Cancer and Possible Treatments Using Nutrition” Life of the Scholar Multidisciplinary Conference, Boiling Springs, North Carolina 2010.
Sanchez K and Ciesielski CJ “ICAM-1 up-regulation on bEND.3 endothelial cells by TNF-alpha. Adrian Tinsley Program (ATP) for Undergraduate Research, Bridgewater, Masschusetts 2008.
Ciesielski CJ, Holderbaum D, Moskowitz RW, Carson D and Corr M. “Single nucleotide polymorphisms in FRZB in hereditary chondrolysis syndrome.” ACR 66th Annual Scientific Meeting, New Orleans, Louisana 2002.
Lindsay JO, Ciesielski CJ, Brennan F and Hodgson HJF. “The rectal administration of an adenoviral vector encoding IL-10 induced colonic IL-10 release with minimal anti-adenoviral response.” Digestive Disease Week, Atlanta, GA, 2001.
Lindsay JO, Ciesielski CJ, Scheinin T, Brennan F and Hodgson HJF. “The prevention and treatment of murine colitis using adenoviral vectors encoding interleukin-10. British Society of Gastroenterology. Glascow, Scotland, 2001.
Ciesielski CJ. “Cognate monocytic MIP-1a production.” Cell Contact Interaction in Rheumatology. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, England, UK 2000.
Ciesielski CJ, Hunt A, Denys A, Brennan F, Feldmann M and Foxwell BMJ. “Use of adenoviral vectors to determine the role of the p38 MAPK signaling pathway in the regulation of TNFa biosynthesis in primary human monocytes.” 8th International TNF Congress. Trondheim, Norway 2000.
Lindsay JO, Ciesielski CJ, Brennan F and Hodgson HJF. "The stable infection of epithelial cell lines and primary rabbit colon cells with an adenovirus encoding murine IL-10 generates bioactive cytokine at therapeutic concentrations.” British Society of Gastroenterology. Birmingham, England, UK 2000.
Ciesielski CJ, Brennan FM, Foxwell BMJ and Feldmann M. “Monocytic MIP-1alpha production induced by cognate interaction with anti-CD3 antibody stimulated T cells is NF-kB dependent.” Keystone Symposia: NF-kappaB Regulation and Function: From Basic Research to Drug Development. Tahoe City, California, 2000.
Ciesielski CJ and Piccinini LA. “Methotrexate treatment affects cell adhesion molecule expression in recipients of rat cardiac allografts.” The 16th Annual International Society for Heart and Lung Transplantation. New York, New York, 1996.
Ciesielski CJ and Piccinini LA. “Effects of cyclosporine and methotrexate upon induction of TNF in rat cardiac allograft rejection.” The 9th International Congress of Immunology. San Francisco, California, 1995.
Ciesielski CJ, Pflug JJ and Piccinini LA. “Combination cyclosporine/methotrexate treatment lowers cell adhesion molecule expression in rat cardiac allografts.” The 23rd Annual Autumn Immunology Conference, Chicago, Illinois, 1994.
Ciesielski CJ and Piccinini LA. “Induction of ICAM-1 and LFA-1 as early markers of rat cardiac allograft rejection.” IBC Third Annual Cell Adhesion Molecule Meeting: Targeting Cell Adhesion Molecules for Therapeutic Applications. San Francisco, California, 1994.